High throughput DNA sequencing technology has been revolutionized in recent years.
This technological boom brought with it a wealth of high quality sequencing datasets, produced by groups around the world.
An important application of DNA sequencing is exploring adaptive immune receptor repertoires (AIRR), in which many of the immune system’s secrets are hidden.
VDJbase is a publicly available database that offers easy searching of genotype and haplotype data inferred from AIRR-seq datasets. From these data we can explore the variability of the genomic loci of the Ig and TR encoding genes across populations.
Use our search page to find open datasets
VDJbase is designed to act as a resource for the scientific community that is interested in exploring the genetic dynamics of the Ig and TR gene loci. The search engine page allows interactive browsing and running database queries. Data is available for bulk download and filtering according to certain metadata parameters. It can also assist in exploring antibody related genetic predisposition to diseases.
Obtain a statistical view on any open dataset by click on the “Export Graph” buttons at the left of the page
VDJbase hosts online tools to assist in visualization and analysis of the genotype and haplotype data. It enables users to determine which allele and genes are significantly over-represented in a particular population, in terms of genotype, haplotype and VDJ gene expression. All analysis can be downloaded as friendly visualization graphs. Users can obtain an online interactive graphs which allows to modify parameters according to their interest.
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